Infection and Immunity (NCCS)

Infection and Immunity


​B cells recognize antigen through their surface Ig-receptors and present it in the context of MHC-II molecules to CD4+ T cells. Recent evidences indicate that B cells also present exogenous antigens in the context of MHC-I to CD8+ T cells and thus, may play an important role in the modulation of CTL responses. However, in this regard conflicting reports are available. One group of studies suggest that the interaction between B cells and CD8+ T cells leads to the activation of the T cells while others propose that it induces T cell tolerance. The laboratory currently focuses on discerning this dichotomy.




Contact info

Address: National Centre for Cell Science NCCS Complex, Pune University Campus Ganeshkhind
City: Pune
Postal code: 411 007
Region: Maharastra
Telephone: +91 020 25708283
Fax: +91 020 25692259

Top Publications